Effective bone regeneration and wound healing with LASAK products

As one of the very few implant manufacturers, LASAK not only manufactures its implants but also the bone grafts in its own production facility. For the treatment of bone defects, LASAK provides bone substitute materials that represent a valuable alternative to autologous bone. They provide a stable scaffold for new bone formation. Both materials for bone grafting from LASAK have no risk of immunological reactions or infection transmission and have human-like bone structure.

The fully resorbable bone substitute, PORESORB-TCP, creates a stable chemical bond between bone tissue and the implant without the formation of a soft tissue interlayer. The volume-stable bone graft OssaBase-HA is slowly resorbed by the bone, making it a perfect scaffold for fast and stable bone formation. The healing process is supported by the resorbable collagen membrane Collagene AT®, which acts as a barrier membrane in the augmented area for a predictable time.

 

 

Fully resorbable bone graft PORESORB-TCP

PORESORB-TCP is theStructure of the fully resorbable bone graft PORESORB-TCP synthetic, resorbable, microporous bone regeneration material based on phase-pure tricalcium phosphate. Since it does not contain any protein, there is no infection risk. The material structure is similar to that of bone and has two main porosity sizes: macro and micro pores. The microstructure of the PORESORB-TCP surface supports the ingrowth of the osteoblasts, which ensure new bone formation. The PORESORB-TCP granulate is ready for immediate use and can be applied directly to the defect after briefly mixing it with patient’s blood, autologous bone, PRP (Platelet-Rich Plasma) or PRGF (Plasma Rich in Growth Factors). In the later phases of bone regeneration, the material gradually disintegrates and is replaced by newly formed bone tissue. For guided bone regeneration, it is recommended to cover the defect with a barrier membrane (e.g., collagen membrane Collagene AT®) to prevent the migration of soft tissue cells into the surface layers of the PORESORB-TCP granulate.

Sinus lift using PORESORB-TCP 1. Situation before sinus grafting
2. Situation six months after sinus lift and before implant insertion
(Dr. Miguel David Cevallos Lecaro, Ph.D., D.C.M. Klinik)

 

Areas of application in dental implantology and periodontology:

  • Sinus lift
  • Filling of bone defects after tooth extraction for prevention of alveolar atrophy
  • Treatment of bone defects in the area around the implant; creation of an implant bed, including immediate or early implantation
  • Augmentation of the alveolar ridge
  • Treatment of periodontal bone defects, peri-implantitis
  • Bone regeneration after the extirpation of cysts

Sinus lift using PORESORB-TCPSeven months after sinus lift: The new formed bone is in direct contact with particles of PORESORB-TCP. The arrows show the newly formed bone in bone grafts pores. (Dr. Miguel David Cevallos Lecaro, Ph.D., D.C.M. Klinik)

 

 

Volume-stable material for bone regeneration OssaBase-HA

Structure of the volume-stable bone graft OssaBase-HAThe synthetic bone substitute material, OssaBase-HA, based on hydroxyapatite, has the structure and composition, and workability, similar to natural bone. It ensures the replacement of missing or lost bones without the risk of immunological reactions or pathogen transmission. It features up to 83% interconnected porosity to support vascularized bone formation. Its low substitution rate helps to ensure long term implant stability and maintain volume when a longer healing time is required. It has high osteoconductivity for safe bone regeneration. The nanostructure of the large specific surface allows easy preparation by cutting instruments during later implantation. It is placed into the defect independently or in combination with autologous bone tissue, blood, PRP (Platelet-Rich Plasma) or PRGF (Plasma Rich in Growth Factors).

Excellent osteoconductive properties of OssaBase-HA
1. Three months postoperatively: Most of the surface of OssaBase-HA granulate (O) is covered with a relatively narrow layer of the newly formed bone (NB; BIC = 73%).
2. Six months postoperatively: The newly formed vital bone (NB) already takes up the majority of the intergranular spaces between the OssaBase-HA particles (O).
3. Osteoconduction in detail: The OssaBase-HA bone graft is in direct contact with the newly formed bone (NB). The bone bridge connects the individual particles of OssaBase-HA and the inorganic bone matrix with bone trabeculae. The arrows show the osteoid layer on the periphery of the newly formed bone.

 

Areas of application in dental implantology and periodontology:

  • Augmentation of the alveolar ridge
  • Treatment of periodontal bone defects
  • Filling of bone defects after tooth extraction for prevention of alveolar atrophy
  • Treatment of bone defects in the area around the implant, creation of an implant bed, including immediate or early implantation
  • Sinus lift
  • Bone augmentation after tumor removal
  • Support function for a membrane used for guided tissue regeneration (GTR)

Specific surface areas of OssaBase-HA, Bio-Oss and othersSpecific surface areas of bone grafts (m2/g). (Weibrich, Wagner et al, Mund Kiefer GesichtsChir, 2000/OssaBase-HA Data File, LASAK Ltd.)

 

 

Barrier membrane Collagene AT®

Resorbable collagen membrane Collagene ATLASAK expanded its product portfolio for dental implantology to include the resorbable collagen membrane Collagene AT®, which is mainly used for guided bone regeneration (GBR) and guided tissue regeneration (GTR). It holds the bone graft in place and prevents the undesired migration of soft tissues into the augmentation area. The collagen membrane functions optimally as a framework for the development of bones, soft tissue and blood vessels and enables the exchange of important nutrients in the early stages of healing. In this way it supports the healing process. Collagene AT® is of equine origin and is completely absorbed naturally within 180 days, so that a second surgery to remove it is not necessary. It is very flexible and is made from pure, non-allergic, lyophilized collagen.

 

Areas of application in dental implantology:

  • Filling of postextraction sockets and periodontal defects/pockets
  • Reconstruction of the atrophied alveolar ridge
  • Sinus lift
  • Oroantral communication
  • Regeneration in periapical surgery after apectomies
  • Treatment after tooth extraction
  • In all cases of oral surgery where bone augmentation is necessary

 

 

Clinical experience for 30 years

LASAK emphasizes the clinical evidence supporting its products, which have been developed in co-operation with dentists for 30 years. The products’ long-term success is, therefore, documented by a number of clinical and experimental studies.